Pub. date: 2008 | Online Pub. Date: November 27, 2007 | DOI: 10.4135/9781412953948 | Print ISBN: 9781412928168 | Online ISBN: 9781412953948| Publisher:SAGE Publications, Inc.About this encyclopedia
The case-cohort design was proposed by Ross Prentice as an alternative design in epidemiologic follow-up studies that is less expensive than a full-scale cohort study. The case-cohort design involves collecting covariate data only for cases, that is, subjects who experience the event of interest in a cohort, and for members of a relatively small randomly selected subcohort. The subcohort may serve as a comparison group for several different types of disease outcomes. The case-cohort design can substantially reduce cost and effort of exposure assessment by limiting exposure to a small fraction of the cohort with only a small loss of efficiency compared with a full cohort design. The case-cohort design is most beneficial when the most expensive part of the study is not in ascertaining subjects but in measuring their exposures. If the main cost is in ascertainment, a full cohort analysis might be a more sensible approach to analysis. ...