Paget's Disease of Bone

David B. Bumpass & Francis H. Shen & Dino Samartzis

Paget's disease, also known as osteitis deformans, is a condition caused by an initial increase in the breakdown of bone followed by chaotic, atypical creation of replacement bone. Paget's disease is the second most common bone disease following osteoporosis. In the United States, Paget's disease is prevalent in 3 to 4 percent of the general population older than 40 years of age. Globally, Paget's disease is present in approximately 10 percent of the population older than 80 years of age. Overall, Paget's disease is present in males and females with a ratio of 1.8:1. This disease bears resemblance only in name to other diseases named after the 19th century British pathologist Dr. James Paget, such as Paget's disease of the breast. In a healthy adult, breakdown of bone is balanced with formation of new bone, so that no net increase in bone mass occurs. Paget's disease begins when osteoclasts (the ...

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