Chapter 21: Cell Therapy: A Decade of Opportunity

Cell therapy: A decade of opportunity Tissue engineering uses cells to regenerate, repair, or replace tissue lost as a result of disease, trauma, or congenital disorders. The three segments of tissue engineering are the ex vivo growth of tissue using cell-seeded matrices, the in vivo promotion of tissue growth stimulated by the implantation of biomaterials, and the transplantation of living cells, known as cell therapy. In cell therapy, which is the focus of this report, scientists engineer cells to accomplish specific therapeutic tasks as well as repair tissue in the body. Cell therapy has applications in the treatment of a variety of disorders, including oncological, musculoskeletal, metabolic, infectious, and autoimmune diseases. Market opportunities for cell therapy applications are substantial. In 2001, for example, the market for chronic congestive heart failure therapies was valued at $2.7 billion in the seven major pharmaceutical markets (United States, France, Germany, Italy, Spain, United Kingdom, ...

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