Chapter 23: Clinical Proteomics: An Engine for In vitro Diagnostics Growth?

Clinical proteomics: An engine for in vitro diagnostics growth? Use of proteomics as a tool to discover new diagnostic markers is drawing significant interest, despite the emphasis on genomics. Whereas genomics provides a basis for the development of new nucleic-acid-based diagnostic tests, proteomics focuses on proteins for the development of new protein-based diagnostics and expression proteomics focuses on determining the quantitative differences in expression of proteins characteristic of normal and pathological states. A number of clinical proteomics business models exist, including tools companies, service companies, companies developing diagnostic assays based upon proprietary technology, and hybrid companies. We review companies pursuing these various models in this chapter, which also provides an explanation of the potential value of proteomics, a review of technology developments and challenges, and a report on ongoing research. The expression of proteins is a complex, dynamic process influenced by cellular interactions, states of cellular differentiation, environmental conditions, and ...

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