Chapter 33: Renin Inhibitors: A Novel Approach to Hypertension

Renin inhibitors: A novel approach to hypertension Hypertension, or high blood pressure (BP), is a significant health concern worldwide. It is a major risk factor for cardiovascular disease (CVD), and poorly controlled hypertension, especially if prolonged, can damage target organs, such as the heart, kidneys, the retina of the eye, and the brain. Over time, this target organ damage can result in heart failure, end-stage kidney disease, retinopathy, stroke, and vascular dementia. Essential hypertension (hypertension with no known cause) accounts for approximately 90% of hypertension and is usually treated with oral antihypertensive drugs. In 2005, the market for these agents exceeded $25 billion in the seven major pharmaceutical markets under study (United States, France, Germany, Italy, Spain, United Kingdom, and Japan). Overall, the treatment of hypertension represents one of the largest markets for prescription drugs. Renin inhibitors are a novel class of drugs in development for the treatment of hypertension. ...

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