Chapter 36: Impact of the PROactive Study on the Treatment of Type 2 Diabetes

Impact of the proactive study on the treatment of type 2 diabetes Type 2 diabetes is a chronic and progressive disease that is frequently linked with long-term microvascular events that cause morbidity (neuropathy, nephropathy, retinopathy, micro-angiopathy) as well as macrovascular events that cause morbidity and mortality (coronary artery disease, stroke, peripheral vascular disease). Moreover, type 2 diabetes is the primary cause of end-stage renal disease worldwide. The life-threatening complications of this disease constitute a significant unmet medical need worldwide, particularly because the prevalence of type 2 diabetes has soared in recent years as a result of changing eating habits and lifestyles. The therapeutic goals with every type 2 diabetes patient are maintenance of eug-lycemia (a normal level of glucose in the blood) and evasion of long-term diabetic complications, including the prevention of cardiovascular events. Several classes of oral antidiabetic drugs, including insulin, are available to manage glycemic control and the ...

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