Chapter 40: How Are Translational Medicine Biomarkers Impacting Industry?

How are translational medicine biomarkers impacting industry? Many experts believe that the future of the pharmaceutical industry hinges upon the development of new and better translational approaches. Failure rates for the development of new drugs will continue to rise if basic research findings cannot be quickly turned into valuable medicines. The result of increasing drug failures will be a pharmaceutical industry that is unsustainable; an industry that will not be able to refresh lean drug development pipelines merely by pushing more preclinical projects into development. As a result, translational medicine is one of the fastest growing areas of drug discovery and development today. Biomarkers are at the heart of this effort. Today, companies want to understand more about how drugs actually work before putting them into pivotal clinical trials, let alone onto the market. Because biomarkers can be used to actually confirm hypotheses and even to bridge preclinical and clinical ...

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