Pub. date: 2008 | Online Pub. Date: September 15, 2008 | DOI: 10.4135/9781412963954 | Print ISBN: 9781412959087 | Online ISBN: 9781412963954 | Publisher:SAGE Publications, Inc.About this encyclopedia
Aastrom Biosciences, Inc.
AASTROM IS A regenerative medicine company developing autologous cell products for the repair or regeneration of multiple human tissues, based on its proprietary tissue repair cell (TRC) technology. Aastrom is a private biotechnology company based out of Ann Arbor, Michigan, with a board of directors composed of individuals with broad experience at both large public and private biotech and pharmaceutical companies. Aastrom's TRCs are a proprietary mixture of bone marrow—derived adult stem and progenitor cells produced using patented single—pass perfusion technology in the Aastrom Replicell system. The clinical procedure begins with the collection of a small sample of bone marrow from the patient's hip in an outpatient setting. TRCs are then produced in the automated Replicell system over a 12—day period. It has been demonstrated in the laboratory that TRCs are able to develop into different types of tissue lineages in response to inductive signals, including blood, bone, cartilage, adipose, ...