PrintShare
Text size Increase font sizeDecrease font size
Encyclopedia of Stem Cell Research

iconEncyclopedia

Encyclopedia of Stem Cell Research

Clive N. Svendsen & Allison D. Ebert

Pub. date: 2008 | Online Pub. Date: September 15, 2008 | DOI:http://dx.doi.org/10.4135/9781412963954 | Print ISBN: 9781412959087 | Online ISBN: 9781412963954 | Publisher:SAGE Publications, Inc.

About this encyclopedia
PrintShare
Text size Increase font sizeDecrease font size
Text size

Viral Vectors: Lentivirus

Jessica Arabski

LENTIVIRAL VECTORS ARE derived from a genus of retroviruses and used as a tool in gene therapy for administering genetic material. Gene therapy frequently uses stem cells because of their self—renewing properties, which allow one—time, as opposed to repeated, delivery of therapeutic genes. Len—tiviruses are unique for their ability to integrate into the genome of both dividing and nondividing cells. Because stem cells are often quiescent, or nondividing, for long periods until activation, len—tiviral vectors provide a way to deliver therapeutic genes and engineer cells capable of proliferating and repairing damaged cells comprising tissues and organs. Although lentivirus offers advantages over other viral vectors, its use in therapy can present potential risks. Lentiviruses are characterized by persistent infection, and viruses proliferate within host cells undetected for extended periods of time. Like other retroviruses, lentiviruses are composed of RNA and, on infecting a host, are reverse—transcribed into DNA that is then ...

Users without subscription are not able to see the full content on this title. Please, subscribe or login to access all content on this website.